QWO®, the FDA’s first and only approved injectable for the treatment moderate to severe cellulite on the buttocks. Prior to QWO®, the only cellulite treatments available were restricted to those which use radio frequency and similar means to disrupt fat cells. By contrast, QWO® is able to address the structural issues which cause cellulite thereby providing a more effective, long term solution.
Cellulite’s characteristic dimples are caused by three things: skin thinning, fat cells expanding and pushing against the skin, fibrous bands beneath the skin’s surface, tension, and skin becoming thinner.
QWO® is made up of enzymes called collagenases. These enzymes target structural causes beneath the skin where cellulite begins.QWO® is thought to release fibrous bands, distribute fat cells and stimulate the growth of new collagen.
If you struggle with cellulite, you are not alone. Although the media, entertainment and advertising industries rarely show cellulite, about 90% of women have it at some visible level. Cellulite affects women regardless of how large or small they are, how much they eat or diet, and how much they exercise.
The anatomical cause of cellulite in the body are ﬁbrous bands of collagen called septae. The ﬁbrous bands in women with cellulite form small pockets of trapped fat. These trapped fat cells become unevenly dispersed causing a dimpling appearance in the skin. It is thought that the propensity toward having these bands is genetic.
Until now, there has not been a long term solution to specifically target cellulite. The most common way to address cellulite has been through treatments that employ mechanical manipulation of the tissue via medical aesthetic devices such as our Velashape 3. These devices incorporate vacuum, massage, and radio frequency heat to reduce the size of these trapped fat cells therefore reducing the appearance of cellulite.
While these methods do effectively reduce the appearance of cellulite, they are less effective at treating the direct cause of the issue i.e., the fibrous bands mentioned previously. Thus, the fat which is disrupted and given a more even appearance by traditional cellulite treatments tends to eventually return to a bulging state due to the bands and the appearance of cellulite eventually returns.
Advanced Skin Fitness has always been the leader in cellulite reduction in Texas. In 2005 the very ﬁrst cellulite treatment was FDA cleared. This device was VelaSmooth. Advanced Skin Fitness was the ﬁrst med spa in Texas to purchase this new technology. We traveled to Canada where we could train with the manufacturer so that we could provide authoritative consultations and informed treatments. Some time later, we introduced Velashape 3 which we still use successfully to improve the appearance of cellulite. While our existing lineup of cellulite therapies have provided the best results available in the industry, we have long awaited a more effective and long term solution.
Now a decade and a half later, we ﬁnally have an FDA cleared, long term solution for the reduction of cellulite. QWO® is the ﬁrst and only FDA approved injectable for cellulite. QWO® has been tested in clinical trials and has been shown to reduce moderate to severe cellulite in adult women in the buttocks. <
QWO® uses an enzyme called collagenase to dissolve the ﬁbrous bands under the skin. When injected around the dimpled skin, QWO® gently release ﬁbrous bands, allows for redistribution of the trapped fat cells, and simulates new collagen growth. Results can be seen in one treatment depending on the severity of the cellulite. However, most will need two treatments and in more severe cellulite cases three treatment could be suggested to see a visual improvement that will deliver patient satisfaction.
QWO® can be combined with Velashape 3 for mechanical manipulation of the fat cells to improve the redistribution of fat to improve the appearance and decrease the activation of QWO® treatment.
The enzymes injected called collagenases target the structural causes under the skin where cellulite starts. It’s thought the QWO® works by releasing ﬁbrous bands, redistributing fat cells, and stimulating the new collagen growth.
At Advanced Skin Fitness we take pride in providing our patients with a treatment plan that is personalized to their speciﬁc goals. To ensure you are a candidate a consultation with an injector will be made prior to treatment. Combination treatments may be recommended to give you the best result possible.
During your consultation your injector will examine the severity of your cellulite and provide you with a treatment plan. Each treatment visit may include up to two treatment areas. QWO® injections will be given three weeks apart for a total of two or three treatment visits.
The prices range from $700-$1,200. Discounts may be available for purchasing multiple areas or combing treatments with other procedures.
Some patients notice less dimpling after a single treatment with QWO®. However, most patents see improvement approximately three weeks after their second injection.
You can expect QWO®’s results to last up to one year, but clinical studies show these results may last much longer. There are no other non-surgical treatments as eﬀective for cellulite reduction.
The most common side effect is injection site bruising and tenderness. In clinical trials, no post-treatment downtime was required.
Are there any other cellulite treatments like QWO® on the market?
No. QWO® is the ﬁrst FDA-approved injectable for moderate to severe cellulite.
Actual patients. Unretouched photos. Before and after images courtesy of Endo Aesthetics.
Patient Medical Information
Do not receive QWO if you:
• Are allergic to any collagenase or to any of the ingredients in QWO. See the end of this Patient Information for a
complete list of ingredients in QWO.
• Have an active infection in the treatment area.
Before receiving QWO, tell your healthcare provider about all of your medical conditions, including if you:
• have had an allergic reaction to a QWO injection in the past
• have a bleeding problem
• are pregnant or plan to become pregnant. It is not known if QWO will harm your unborn baby.
• are breastfeeding or plan to breastfeed. It is not known if QWO passes into your breast milk. Talk to your
healthcare provider about the best way to feed your baby if you receive QWO.
Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines,
vitamins, and herbal supplements. Especially tell your healthcare provider if you take a medicine that prevents the
clotting of your blood (antiplatelet or anticoagulant medicine).
What are the ingredients in QWO?
Active ingredient: collagenase clostridium histolyticum
Inactive ingredients: mannitol, sucrose, tromethamine, and hydrochloric acid
The diluent contains: calcium chloride dihydrate, sodium chloride, and Water for Injection, USP
How will I receive QWO?
• QWO is injected into the fat (subcutaneously) of each single buttock (treatment area) by your healthcare provider. You
may receive up to 12 injections per treatment area.
• Each treatment visit may include up to 2 treatment areas.
• QWO injections will be given 21 days apart for 3 treatment visits.
What are the possible side effects of QWO?
QWO may cause serious side effects, including:
• Allergic (hypersensitivity) reactions, including anaphylaxis. Call your healthcare provider right away if you have
any of these symptoms of an allergic reaction after an injection of QWO:
• swollen face
• trouble breathing o chest pain
• low blood pressure o dizziness or fainting
• Injection site bruising.
The most common side effects of QWO include bruising, pain, areas of hardness, itching, redness, discoloration,
swelling and warmth in the treatment area.
These are not all of the possible side effects of QWO.
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
General information about QWO
Medicines are sometimes prescribed for purposes other than those listed in a Patient Information leaflet. If you would like
more information, talk to your healthcare provider. You can ask your pharmacist or healthcare provider for more
information about QWO that is written for health professionals.
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ADVANCED SKIN FITNESS MEDICAL SPAS AND COOLSULPTING CENTERS have been pioneering and improving non-invasive aesthetic treatments for years. We refuse to settle for out-of-the box, pre-packaged approaches to patient’s needs. Often, the best results come from combinations of treatments. We find the right combination of treatments and approaches for YOUR individual situation to help you realize the best YOU possible.
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